VS2017 Keyboard Shortcuts not working even after settings reset

I've noticed that some of my keyboard shortcuts are not working. I've tried resetting visual studio keyboard settings to default, then reapplying the visual studio theme with resharper, without luck. I've tried a complete restore of visual studio to default everything, and reinstalled resharper, without any difference.

One of the shortcuts I'm trying to use is Control + Shift + S to save all open documents. Control + S is working for save, but save is not working. Visual studio tells me that that Control + Shift + S is correctly assigned to the File.SaveAll shortcut as a global shortcut.

Does anyone have advice for how I can restore this functionality?

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