I have a dual monitor setup and when I press F2 the rename dialog is not positioned properly. If VS is on the first screen I only see the red sign floating on the second screen. If VS is on the second screen then I see the corner of the dialog box and can move it left and use it.
Also the ctrl-e popup appears in the middle of the screen - half on one screen half on the other, not as significant but in 1.5 it used to be handled properly.
OS: Win2000, NVidia Quadro NVS, dual monitors handled by NVidia Multiview, which as far as I understand makes it look like one giant screen to the application.