Using v221 with VS2005:
The indicator in the upper right corner of the editor blinks in a very annoying manner. A red (or green) box alternates with a tiny arrow pointing right. Also the analysis seems to be chugging away constantly, using a constant 25% of my CPU. And finally, I can't get R# to resolve most symbols that are outside the .net framework. I've had this problem for the past 5 or 6 versions but since I mostly use VS2003 I gave up on the problem until now.