I have an intermittent, though frequent, problem with VS2008 hanging early in the startup process when R#5 is installed (it's been going on for a long time with lots of different nightlies).
I cannot say 100% certain that it's R#'s fault (I have other add-ins installed too), but the problem did go away when 4.5 was reinstalled for a while. The hang seems more likely to occur if you interact (e.g. mouse-over the toolbars) with the VS window while it's starting up - if you leave it alone until it's finished starting, there seems to be less of a problem. I always have multiple instances of VS running, I don't know if this is related. Anyone else seen anything like this?
I have taken a procdump dump of the most recent hang - it's only about 5MB zipped (like I say, it's quite early in startup) - should I send this to one of the JB guys by email, or should I file a bug and attached it - can I attach a 5MB zip file to a bug report?