ReSharper very slow in core files (5+ second lockup)

I am developing a reference implemenation web app for my company.  It uses Aurelia with Typescript.

I am finding that if I edit any of the "core" files of the project that resharper locks visual studio up for 5-30 seconds.  This lock up happens after about 5-20 keystrokes.

If I disable resharper, then I can make my edits with no issues.

Currently I just try to remember disable ReSharper before I edit those files.  But I thought I would ask if there is a way to have ReSharper be disabled for specific files.  That way I don't have to wait for it to rebuild the cache when I re-enable it.

So, is there a way to have resharper not be on when in specific files?

For me the files would be:

• index.htm.
• main.ts
• src/app.ts

(Most of the rest of the files work fairly to very well)

I am running:
Visual Studio 2015 Update 1.
Resharper Ultimate 10.0.1