I ran optimize references on our project and it found things that are not used. But it also marked glimpse.dll's as not used. Technically they are not, just in the web.config. Which I'm guessing it does not parse. Thing I'm concerned about is something that is needed is removed. But it can still compile. In my case I think my local dev environment was a bit wonky and coinincidently I blamed R#. I'm going to test it again, but just curious.